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Clinical Trials in Psychopharmacology: A Better Brain
Wiley | 2010 | ISBN: 0470740760 | 406 pages | PDF | 12 MB


Although clinical trials were virtually unheard of in psychiatry for  many years, they are now the gold standard for judging whether drugs are  safe and useful. But should they be? What is the true status of  clinical trials? Even when they ostensibly demonstrate a benefit of a  certain treatment, the strict patient selection criteria, poor  compliance and high drop-out rate leave the conclusions open to  question. Are the new treatments really better or more cost-effective  than the old? Do they have fewer side effects?               In  this book the authors take a critical look at recent developments and  present a series of trenchant and challenging observations. Section I  examines the significant changes in law and the regulatory environment  that have occurred during the past ten years. Has fossilization  handicapped the US Food and Drug Administration in promoting treatment  advances? How can the plethora of findings be regulated? This is  particularly pertinent in genomic studies and there are two chapters  addressing the impact of genomics on psychiatric research. This section  also addresses the role of women in drug trials – a group long excluded  but now demanding a part, for without testing how can optimal treatments  be devised? The next two Sections highlight clinical trials in the major areas of  psychiatric pharmacological treatment, including Mood Disorders,  especially Bipolar, Anxiety Disorders, and addictions. Chapters on  pharmacological treatments for Eating Disorders, Attention Deficit  Disorder, Autism and Asperger’s Syndrome, and Impulse Control Disorder  represent the latest thinking on these subjects. The final Section contains a consummate example of out-of-the [Western]-  box thinking, namely consideration of herbal medicines – used by a  large number of patients, with or without medical supervision. We  conclude with a close look at the problem of side effects, then selected  thoughts about methodology. Clearly written, the text provides immediate access to new developments  across the spectrum of drug testing. Clinical Trials in  Psychopharmacology: A Better Brain is provocative reading for  psychiatrists, pharmacologists and all those interested in improved drug  treatments for patients with mental illness.
•Raises questions about the conduct of trials and the credibility of  their outcomes that are relevant not just in psychiatry but all areas of  medicine
•Discusses the ethical problems in assessing outcomes in humans,  including children

                                
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